Hi Harish,
What is the purpose of this RFC Lookup? Are you trying to update one RFC in Lookup and another one as RFC Receiver?
Do the RFC Response coming back from your Lookup required to build Request Message of the RFC Receiver? If NO and you are using Lookup only to update the tables through RFC, change your design.
You should either use one RFC (Custom / Standard Function Module or BAPI) to take care of all the Table updates / access at ECC side or use ABAP Proxy. Proxy has better performance and enhanced monitoring capabilities. You will find lot of information on SCN that why Proxy is better over RFC.
Regards,
Nabendu.